After a clean install, some users have reported that changing the resolution to anything but 640×480 will cause the game to crash to desktop on subsequent startups. It some cases this is a silent crash where the game appears to be starting but the silently aborts startup. You can fix this crash by changing some settings in your settings.txt file. The Dead Space settings.txt file is located in:
C:\Users\<YOU>\AppData\Local\Electronic Arts\Dead Space\settings.txt
Keep in mind AppData is a hidden folder so you’ll have to enable show hidden folders in order to see it. To fix this resolution related crash remove the following lines from the settings file:
Window.Top = 0
Window.Left = 0
If that doesn’t work you can also try deleting this settings.txt file to completely reset all the settings for the game back to their defaults.
If you’ve followed the above steps and are still having issues with the Deadspace resolution change crash, please post in the comments below. To increase your chances of a solution being found include as much detail as possible (which version of the game you’re running, what operating system you have, what video card you have and steps to reproduce the issue). Screenshots are also very useful!